PDF Ebook The Emperor of All Maladies: A Biography of Cancer, by Siddhartha Mukherjee
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The Emperor of All Maladies: A Biography of Cancer, by Siddhartha Mukherjee
PDF Ebook The Emperor of All Maladies: A Biography of Cancer, by Siddhartha Mukherjee
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Amazon.com Review
Amazon Best Books of the Month, November 2010: "In 2010, about six hundred thousand Americans, and more than 7 million humans around the world, will die of cancer." With this sobering statistic, physician and researcher Siddhartha Mukherjee begins his comprehensive and eloquent "biography" of one of the most virulent diseases of our time. An exhaustive account of cancer's origins, The Emperor of All Maladies illustrates how modern treatments--multi-pronged chemotherapy, radiation, and surgery, as well as preventative care--came into existence thanks to a century's worth of research, trials, and small, essential breakthroughs around the globe. While The Emperor of All Maladies is rich with the science and history behind the fight against cancer, it is also a meditation on illness, medical ethics, and the complex, intertwining lives of doctors and patients. Mukherjee's profound compassion--for cancer patients, their families, as well as the oncologists who, all too often, can offer little hope--makes this book a very human history of an elusive and complicated disease. --Lynette Mong
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From Publishers Weekly
Starred Review. Mukherjee's debut book is a sweeping epic of obsession, brilliant researchers, dramatic new treatments, euphoric success and tragic failure, and the relentless battle by scientists and patients alike against an equally relentless, wily, and elusive enemy. From the first chemotherapy developed from textile dyes to the possibilities emerging from our understanding of cancer cells, Mukherjee shapes a massive amount of history into a coherent story with a roller-coaster trajectory: the discovery of a new treatment--surgery, radiation, chemotherapy--followed by the notion that if a little is good, more must be better, ending in disfiguring radical mastectomy and multidrug chemo so toxic the treatment ended up being almost worse than the disease. The first part of the book is driven by the obsession of Sidney Farber and philanthropist Mary Lasker to find a unitary cure for all cancers. (Farber developed the first successful chemotherapy for childhood leukemia.) The last and most exciting part is driven by the race of brilliant, maverick scientists to understand how cells become cancerous. Each new discovery was small, but as Mukherjee, a Columbia professor of medicine, writes, "Incremental advances can add up to transformative changes." Mukherjee's formidable intelligence and compassion produce a stunning account of the effort to disrobe the "emperor of maladies." (Nov.) (c) Copyright © Reed Business Information, a division of Reed Elsevier Inc. All rights reserved.
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Product details
Hardcover: 592 pages
Publisher: Scribner; 1 edition (November 16, 2010)
Language: English
ISBN-10: 9781439107959
ISBN-13: 978-1439107959
ASIN: 1439107955
Product Dimensions:
6.1 x 1.6 x 9.2 inches
Shipping Weight: 1.9 pounds (View shipping rates and policies)
Average Customer Review:
4.7 out of 5 stars
1,749 customer reviews
Amazon Best Sellers Rank:
#22,189 in Books (See Top 100 in Books)
Interesting. Informative. Frightening facts. These several words say it all, as far as I am concerned. This non-fiction book is written like a thriller. The reader is the antagonist and cancer is the protagonist no one wants to meet.Obviously, a great deal of research went into the writing of this book: Frightening research makes it all worth the reading, all 500 plus pages.Everything you can possibly think about asking about cancer is included here. Well done and easily understood for a subject no one ever wants to encounter firsthand. I highly recommend this as a worthwhile read.
Last April I was diagnosed with acute leukaemia. After a stem cell transplant I am coming up for a year.When you are told you have cancer you are bewildered. You are also very angry. I asked myself was there something I had done in my past that was going to deprive me seeing my two sons grow up into happy young men and dads. The first two weeks go by in a weird nightmare. Day 17 your hair falls out. Your peeing orange from the chemo drugs, which have put me off lucozade for life. You double check all your insurances are up to date and update a well to make sure my wife does not have any hassles with the tax authorities. At the age of 44 you are very angry. You realise you are likely going to die. You are angry because you have no idea what is doing it. What you planned for when you were older is all meaningless. But, thanks to certain stubbornness and amazing treatment and care, and a generous sift of life from a German donor of life giving stem cells, I am alive.This book helps explain many of the questions I had. It does it in a way that makes sense if you don't have a degree in science. What was until recently a death sentence is no longer the case. The battle against cancer was waged by intrepid individuals, and this book explains the war so far. It outlines the causes of cancer, whether it is a virus, bacteria, induced by smoking or chemicals, or just our own body playing up and turning on itself. It explains how our own understanding is still basic but advancing year by year, and treatments, if not cures, are being found for many, although not all cancers.I learned that was once a death sentence is not the case today. I am looking forward to see my sons become men. This book gave me clarity, it gave me hope.
I only read this book because Ken Burns produced a documentary on it that is coming out in the Spring of 2015. I really love Ken Burns documentaries, hence the interest. Across the book, there is only one common character, cancer. Although cancer is not a single disease but a collection of several diseases characterized by uncontrolled growth and spread of cells in the body, the book portrays cancer as a great villain, lurking in the shadows, ready to strike at any time. What makes this story different and far from dry is the way S. Mukherjee tells it: "the story of leukemia - the story of cancer - isn't the story of doctors who struggle and survive, moving from one institution to another. It is the story of patients who struggle and survive, moving from one embankment of illness to another. Resilience, inventiveness, and survivorship — qualities often ascribed to great physicians — are reflected qualities, emanating first from those who struggle with illness and only then mirrored by those who treat them. If the history of medicine is told through the stories of doctors, it is because their contributions stand in place of the more substantive heroism of their patients."Across the book, we are also introduced to ways of fighting or stalling the advance of cancer: radical surgery and radical mastectomy, X-rays, cytotoxics, monoclonal antibodies, tyrosine kinase inhibitors and S. Mukherjee explains really well how all of the above function (or don't function in some cases). One of the strengths of the book is that it gives a behind the scenes look at how certain drugs or procedures came to be (Druker's struggles with developing imatinib) or how other procedures were proven to be too radical and changed such as Halsted's radical mastectomy.The fight to find a cure for cancer has triggered enormous social forces in the 20th century and in the book we are introduced to some of the main characters: Sidney Farber and the Jimmy Fund, Mary Lasker and the American Cancer Society both determined to enact policy changes that will get more resources allocated to the war against cancer. These are just a few figures in this war, but there were other forces as well that fought for cigarette labeling for example, or more personal struggles related to compassionate drug use.S. Mukherjee ends the book on a more positive note. All throughout the book we get the impression that primitive forces are battling a very complex disease, using disfiguring surgery or drugs that oftentimes end up causing cancer themselves. The final few chapters are not so gloomy, he takes a molecular biologist's view of the disease and explains our current understanding of the processes and pathways involved and you do get the impression that by 2050 we will be able to target the specific pathways and mutations that make up a particular form of cancer.
This book was outstanding, and one that should be read with care for anyone working in oncology. Although factually interested, I felt the book was slightly dry while reviewing the early history of cancer care. The change in prose was palpable as it transitioned to modern oncology, where the author gave detailed, emotional accounts of his own patient interactions. The last 200 pages were phenomenal and often describes why I chose oncology as a profession. It gives beautiful descriptions of the grit patients have to endure such debilitating disease; transcending the physical body into a higher understanding.
I read this book after being treated with chemo, radiation and surgery for stage II breast cancer. The author's writing is luminous, passionate and powerful. What could have been a dry textbook of voluminous facts becomes an awe-inspiring journey through the history and future of cancer. The author's comprehensive knowledge and sharp intelligence make this book a riveting and compelling page-turner of mammoth scope and extraordinary detail. As a cancer survivor, I highly recommend this book to anyone touched by the disease.
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